What is Glioma?
Glioma is a common type of tumor originating in the brain. About 33 percent of all brain tumors are gliomas, which originate in the glial cells that surround and support neurons in the brain, including astrocytes, oligodendrocytes and ependymal cells. Click HERE to learn more from Hopkins Medicine
Glioblastomas (also called GBM) are the most invasive type of glial tumors and represent about 15% of all primary brain tumors. Glioblastomas are infiltrative and invade into nearby regions of the brain. They can also sometimes spread to the opposite side of the brain through connection fibers (corpus callosum). (Info from the ABTA) Information from the AANS
PDGFRA Amplification in Glioblastoma
Amplification of the PDGFRA gene occurs in approximately 15% of glioma patients. Multiple reports over the last 10 years provide increasing evidence that the PDGFR pathway plays a key role in both the development of normal glial cells as well as in primary and secondary low and high grade gliomas. All of these reports, based on both gene copy number and gene expression analyses, suggest that PDGFRα is an important therapeutic target for malignant gliomas.